186 research outputs found
Comparison of A-mode and B-mode Ultrasound for Measurement of Subcutaneous Fat
With lower-cost devices and technologic advancements, ultrasound has been undergoing a resurgence as a method to measure subcutaneous adipose tissue. We aimed to determine whether a low-cost, 2.5-MHz amplitude (A-mode) ultrasound, designed specifically for body composition assessment, could produce subcutaneous fat thickness measurements comparable to an expensive, 12-MHz brightness (B-mode) device. Fat thickness was measured on 40 participants (20 female, 20 male; 29.7 ± 11.1 y of age; body mass index 24.9 ± 4.5 kg/m2) at 7 sites (chest, subscapula, mid-axilla, triceps, abdomen, suprailiac and thigh) with both devices. Intraclass correlations exceeded 0.75 at all measurement sites. Mean differences in fat thickness were not significantly different (p \u3e 0.05) and within ± 1.0 mm. Variability between devices was greatest at the abdomen, the site with the greatest thickness. The low-cost, low-resolution A-mode ultrasound provides subcutaneous fat thickness measurements similar to the more expensive, high-resolution B-mode ultrasound
Exploiting the UMLS Metathesaurus for extracting and categorizing concepts representing signs and symptoms to anatomically related organ systems
AbstractObjectiveTo develop a method to exploit the UMLS Metathesaurus for extracting and categorizing concepts found in clinical text representing signs and symptoms to anatomically related organ systems. The overarching goal is to classify patient reported symptoms to organ systems for population health and epidemiological analyses.Materials and methodsUsing the concepts’ semantic types and the inter-concept relationships as guidance, a selective portion of the concepts within the UMLS Metathesaurus was traversed starting from the concepts representing the highest level organ systems. The traversed concepts were chosen, filtered, and reviewed to obtain the concepts representing clinical signs and symptoms by blocking deviations, pruning superfluous concepts, and manual review. The mapping process was applied to signs and symptoms annotated in a corpus of 750 clinical notes.ResultsThe mapping process yielded a total of 91,000 UMLS concepts (with approximately 300,000 descriptions) possibly representing physical and mental signs and symptoms that were extracted and categorized to the anatomically related organ systems. Of 1864 distinct descriptions of signs and symptoms found in the 750 document corpus, 1635 of these (88%) were successfully mapped to the set of concepts extracted from the UMLS. Of 668 unique concepts mapped, 603 (90%) were correctly categorized to their organ systems.ConclusionWe present a process that facilitates mapping of signs and symptoms to their organ systems. By providing a smaller set of UMLS concepts to use for comparing and matching patient records, this method has the potential to increase efficiency of information extraction pipelines
Behavioral Mechanisms, Elevated Depressive Symptoms, and the Risk for Myocardial Infarction or Death in Individuals With Coronary Heart Disease The REGARDS (Reason for Geographic and Racial Differences in Stroke) Study
ObjectivesThe aim of this study was to determine whether behavioral mechanisms explain the association between depressive symptoms and myocardial infarction (MI) or death in individuals with coronary heart disease (CHD).BackgroundDepressive symptoms are associated with increased morbidity and mortality in individuals with CHD, but it is unclear how much behavioral mechanisms contribute to this association.MethodsThe study included 4,676 participants with a history of CHD. Elevated depressive symptoms were defined as scores ≥4 on the Center for Epidemiologic Studies Depression 4-item Scale. The primary outcome was definite/probable MI or death from any cause. Incremental proportional hazards models were constructed by adding demographic data, comorbidities, and medications and then 4 behavioral mechanisms (alcohol use, smoking, physical inactivity, and medication non-adherence).ResultsAt baseline, 638 (13.6%) participants had elevated depressive symptoms. Over a median 3.8 years of follow up, 125 of 638 (19.6%) participants with and 657 of 4,038 (16.3%) without elevated depressive symptoms had events. Higher risk of MI or death was observed for elevated depressive symptoms after adjusting for demographic data (hazard ratio [HR]: 1.41, 95% confidence interval [CI]: 1.15 to 1.72) but was no longer significant after adjusting for behavioral mechanisms (HR: 1.14, 95% CI: 0.93 to 1.40). The 4 behavioral mechanisms together significantly attenuated the risk for MI or death conveyed by elevated depressive symptoms (−36.9%, 95% CI: −18.9 to −119.1%), with smoking (−17.6%, 95% CI: −6.5% to −56.0%) and physical inactivity (−21.0%, 95% CI: −9.7% to −61.1%) having the biggest explanatory roles.ConclusionsOur findings suggest potential roles for behavioral interventions targeting smoking and physical inactivity in patients with CHD and comorbid depression
What Next-Generation 21 cm Power Spectrum Measurements Can Teach Us About the Epoch of Reionization
A number of experiments are currently working towards a measurement of the 21
cm signal from the Epoch of Reionization. Whether or not these experiments
deliver a detection of cosmological emission, their limited sensitivity will
prevent them from providing detailed information about the astrophysics of
reionization. In this work, we consider what types of measurements will be
enabled by a next-generation of larger 21 cm EoR telescopes. To calculate the
type of constraints that will be possible with such arrays, we use simple
models for the instrument, foreground emission, and the reionization history.
We focus primarily on an instrument modeled after the
collecting area Hydrogen Epoch of Reionization Array (HERA) concept design, and
parameterize the uncertainties with regard to foreground emission by
considering different limits to the recently described "wedge" footprint in
k-space. Uncertainties in the reionization history are accounted for using a
series of simulations which vary the ionizing efficiency and minimum virial
temperature of the galaxies responsible for reionization, as well as the mean
free path of ionizing photons through the IGM. Given various combinations of
models, we consider the significance of the possible power spectrum detections,
the ability to trace the power spectrum evolution versus redshift, the
detectability of salient power spectrum features, and the achievable level of
quantitative constraints on astrophysical parameters. Ultimately, we find that
of collecting area is enough to ensure a very high significance
() detection of the reionization power spectrum in even the
most pessimistic scenarios. This sensitivity should allow for meaningful
constraints on the reionization history and astrophysical parameters,
especially if foreground subtraction techniques can be improved and
successfully implemented.Comment: 27 pages, 18 figures, updated SKA numbers in appendi
When nutritional guidelines and life collide: family fruit and vegetable socialisation practices in low socioeconomic communities
Parents play a critical role in promoting fruit and vegetable consumption, for eating patterns established early in life tend to persist into adulthood. Despite this, the factors that facilitate or inhibit parents’ capacity to socialise fruit and vegetable consumption into their children’s daily diets remain poorly defined. Thirty-eight semi-structured interviews with residents, allied healthcare professionals, community leaders, community programme leaders and a local government leader living or working in two low socioeconomic suburbs were consequently conducted to ascertain factors exogenous and endogenous to the family unit that shaped parental food socialisation practices. Budgetary and time constraints emerged as exogenous factors that constrained fruit and vegetable socialisation. Constraining effects were also found for a range of endogenous factors, including commensal experiences, children’s food fussiness and the feeding styles employed by parents. As such, while many caregivers may wish to socialise fruit and vegetable consumption into their children’s daily diets, their capacity to do so is often inhibited by factors beyond their volitional control. Failure to take heed of these factors could therefore result in the development of social marketing campaigns that are ineffective at best or give rise to unintentionally harmful outcomes at worst
Fibromyalgia Syndrome Care of Iraq- and Afghanistan-Deployed Veterans in Veterans Health Administration
Little is known regarding fibromyalgia syndrome (FMS) care among Operation Iraqi Freedom/Operation Enduring Freedom/Operation New Dawn (OIF/OEF/OND) Veterans. Current recommendations include interdisciplinary, teambased combined care approaches and limited opioid use. In this study of OIF/OEF/OND Veterans who accessed Veterans Health Administration services between 2002 and 2012, we hypothesized that combined care (defined as at least 4 primary care visits/yr with visits to mental health and/or rheumatology) versus/yr only would be associated with lower risk of at least 2 opioid prescriptions 12 mo following an FMS diagnosis. Using generalized linear models with a loglink, the Poisson family, and robust standard errors, we estimated risk ratios (RRs) and 95% confidence intervals (CIs). We found that 1% of Veterans had at least 2 FMS diagnoses (International Classification of Diseases-9th Revision-Clinical Modification code 729.1) or at least 1 FMS diagnosis by rheumatology. Veterans with (vs without) FMS were more likely to be female, older, Hispanic, and never/currently married. Combined primary, mental health, and rheumatology care was associated with at least 2 opioid prescriptions (RR [95% CI] for males 2.2 [1.1–4.4] and females 2.8 [0.4–18.6]). Also, combined care was associated with at least 2 nonopioid painrelated prescriptions, a practice supported by evidence-based clinical practice guidelines. In tandem, these results provide mixed evidence of benefit of combined care for FMS. Future studies of healthcare encounter characteristics, care coordination, and benefits for Veterans with FMS are needed
The Hydrogen Epoch of Reionization Array Dish II: Characterization of Spectral Structure with Electromagnetic Simulations and its science Implications
We use time-domain electromagnetic simulations to determine the spectral
characteristics of the Hydrogen Epoch of Reionization Arrays (HERA) antenna.
These simulations are part of a multi-faceted campaign to determine the
effectiveness of the dish's design for obtaining a detection of redshifted 21
cm emission from the epoch of reionization. Our simulations show the existence
of reflections between HERA's suspended feed and its parabolic dish reflector
that fall below -40 dB at 150 ns and, for reasonable impedance matches, have a
negligible impact on HERA's ability to constrain EoR parameters. It follows
that despite the reflections they introduce, dishes are effective for
increasing the sensitivity of EoR experiments at relatively low cost. We find
that electromagnetic resonances in the HERA feed's cylindrical skirt, which is
intended to reduce cross coupling and beam ellipticity, introduces significant
power at large delays ( dB at 200 ns) which can lead to some loss of
measurable Fourier modes and a modest reduction in sensitivity. Even in the
presence of this structure, we find that the spectral response of the antenna
is sufficiently smooth for delay filtering to contain foreground emission at
line-of-sight wave numbers below Mpc, in
the region where the current PAPER experiment operates. Incorporating these
results into a Fisher Matrix analysis, we find that the spectral structure
observed in our simulations has only a small effect on the tight constraints
HERA can achieve on parameters associated with the astrophysics of
reionization.Comment: Accepted to ApJ, 18 pages, 17 Figures. Replacement matches accepted
manuscrip
The Hydrogen Epoch of Reionization Array Dish I: Beam Pattern Measurements and Science Implications
The Hydrogen Epoch of Reionization Array (HERA) is a radio interferometer
aiming to detect the power spectrum of 21 cm fluctuations from neutral hydrogen
from the Epoch of Reionization (EOR). Drawing on lessons from the Murchison
Widefield Array (MWA) and the Precision Array for Probing the Epoch of
Reionization (PAPER), HERA is a hexagonal array of large (14 m diameter) dishes
with suspended dipole feeds. Not only does the dish determine overall
sensitivity, it affects the observed frequency structure of foregrounds in the
interferometer. This is the first of a series of four papers characterizing the
frequency and angular response of the dish with simulations and measurements.
We focus in this paper on the angular response (i.e., power pattern), which
sets the relative weighting between sky regions of high and low delay, and
thus, apparent source frequency structure. We measure the angular response at
137 MHz using the ORBCOMM beam mapping system of Neben et al. We measure a
collecting area of 93 m^2 in the optimal dish/feed configuration, implying
HERA-320 should detect the EOR power spectrum at z~9 with a signal-to-noise
ratio of 12.7 using a foreground avoidance approach with a single season of
observations, and 74.3 using a foreground subtraction approach. Lastly we study
the impact of these beam measurements on the distribution of foregrounds in
Fourier space.Comment: 13 pages, 9 figures. Replaced to match accepted ApJ versio
Can a Point-of-Care Troponin I Assay be as Good as a Central Laboratory Assay? A MIDAS Investigation.
BACKGROUND: We aimed to compare the diagnostic accuracy of the Alere Triage Cardio3 Tropinin I (TnI) assay (Alere, Inc., USA) and the PathFast cTnI-II (Mitsubishi Chemical Medience Corporation, Japan) against the central laboratory assay Singulex Erenna TnI assay (Singulex, USA).
METHODS: Using the Markers in the Diagnosis of Acute Coronary Syndromes (MIDAS) study population, we evaluated the ability of three different assays to identify patients with acute myocardial infarction (AMI). The MIDAS dataset, described elsewhere, is a prospective multicenter dataset of emergency department (ED) patients with suspected acute coronary syndrome (ACS) and a planned objective myocardial perfusion evaluation. Myocardial infarction (MI) was diagnosed by central adjudication.
RESULTS: The C-statistic with 95% confidence intervals (CI) for diagnosing MI by using a common population (n=241) was 0.95 (0.91-0.99), 0.95 (0.91-0.99), and 0.93 (0.89-0.97) for the Triage, Singulex, and PathFast assays, respectively. Of samples with detectable troponin, the absolute values had high Pearson (R(P)) and Spearman (R(S)) correlations and were R(P)=0.94 and R(S)=0.94 for Triage vs Singulex, R(P)=0.93 and R(S)=0.85 for Triage vs PathFast, and R(P)=0.89 and R(S)=0.73 for PathFast vs Singulex.
CONCLUSIONS: In a single comparative population of ED patients with suspected ACS, the Triage Cardio3 TnI, PathFast, and Singulex TnI assays provided similar diagnostic performance for MI
Mapping Cosmic Dawn and Reionization: Challenges and Synergies
Cosmic dawn and the Epoch of Reionization (EoR) are among the least explored
observational eras in cosmology: a time at which the first galaxies and
supermassive black holes formed and reionized the cold, neutral Universe of the
post-recombination era. With current instruments, only a handful of the
brightest galaxies and quasars from that time are detectable as individual
objects, due to their extreme distances. Fortunately, a multitude of
multi-wavelength intensity mapping measurements, ranging from the redshifted 21
cm background in the radio to the unresolved X-ray background, contain a
plethora of synergistic information about this elusive era. The coming decade
will likely see direct detections of inhomogenous reionization with CMB and 21
cm observations, and a slew of other probes covering overlapping areas and
complementary physical processes will provide crucial additional information
and cross-validation. To maximize scientific discovery and return on
investment, coordinated survey planning and joint data analysis should be a
high priority, closely coupled to computational models and theoretical
predictions.Comment: 5 pages, 1 figure, submitted to the Astro2020 Decadal Survey Science
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